Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The investigators recently evaluated 4 different oximeters among the most commonly used with arterial catheter in place and compared SpO2 with SaO2 obtained on arterial gas. Correlations between SaO2 and SpO2 were poor for all oximeters, as previously known, and SpO2-SaO2 bias were different between oximeters. Some oximeters (Masimo, Nellcor) had lower biases but they detected less well hypoxemia. Some oximeters underestimated SaO2 (Nonin) but detected very well hypoxemia, and some overestimated SaO2 (Philips). The investigators concluded that oximeters provide different informations to clinicians, and oxygenation targets should take into account for these differences. The assumption is that the SpO2 target AND oximeter used will both have an impact on oxygen flows and that these effects will add up. With a high SpO2 target, oxygen flows will be significantly greater and with the Nonin oximeter, the required flows will be greater than with the Philips oximeter. NB: the results obtained were in a population with light skin pigmentation (96% of the patients were Fitzpatrick 1-2, reflecting the local hospitalized population).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• ≥ 18 years of age

• Patients admitted to postoperative cardiac surgery intensive care unit

• Presence of an arterial catheter Specific for the extubate patient

• Ongoing on conventional oxygen therapy at moderate flow (up to a maximum of 5L/min) with SpO2 between 88 and 100% with the usual oximeter and nasal cannula.

• SpO2 \< 92% ambient air Specific for the intubate patient FiO2 \<= 0.60 with SpO2 between 88 and 100% with usual oximeter SpO2 \< 92% with FiO2 0.21

Locations
Other Locations
Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec
RECRUITING
Québec
Contact Information
Primary
Francois Lellouche
francois.lellouche@criucpq.ulaval.ca
418656-8711
Backup
Pierre Alexandre Bouchard
pierre-alexandre.bouchard@criucpq.ulaval.ca
418656-8711
Time Frame
Start Date: 2022-11-16
Estimated Completion Date: 2027-06
Participants
Target number of participants: 40
Treatments
Experimental: Nonin oximeter with a 90% SpO2 target
During this periods , oxygen will be administered in an manual titration with the FreeO2 device (fixed flow mode) to reach 90% of SpO2.
Experimental: Philips oximeter with a 90% SpO2 target
During this periods, oxygen will be administered in a manual titration with the FreeO2 device (fixed flow mode), to reach 90% of SpO2.
Experimental: Nonin oximeter with a 94% SpO2 target
During this periods , oxygen will be administered in a manual titration with the FreeO2 device (fixed flow mode) to reach 94% of SpO2.
Experimental: Philips oximeter with a 94% SpO2 target
During this periods, oxygen will be administered in a manual titration with the FreeO2 device (fixed flow mode), to reach 94% of SpO2.
Related Therapeutic Areas
Sponsors
Leads: Laval University

This content was sourced from clinicaltrials.gov